Name | Topic | Title |
---|---|---|
Tumpa Dasgupta | Biochemistry / Chem Bio. | Inter-domain protein-protein interaction in the rapid relaxation of negatively supercoiled DNA by E. coli topoisomerase I |
Mrs. Tumpa Dasgupta | Biochemistry / Chem Bio. | Inter-domain protein-protein interaction in the rapid relaxation of negatively supercoiled DNA by E. coli topoisomerase I |
Alexander Demidov | PMSE/POLY | Structure and Gas Transport Properties of Organic Mixed Matrices: Polymers of Intrinsic Microporosity with Organic Molecules of Intrinsic Microporosity |
Miss Kristie Dick | Environmental | Biogeochemical Cycling of Trace Metals in the Southern Ocean |
Mrs. Lily Diodati | PMSE/POLY | Hierarchical Fractal Assemblies Formed by Poly(ethylene oxide-b-lysine-b-leucine) |
Mr. James Donnelly | Organic Chemistry | 3, 4-Dihydroxyphenylacetaldehyde (DOPAL) is an important intermediate metabolite found in catecholamine neurotransmitter systems. As such, it has an important role in medicinal research directed toward the study of alcoholism, Alzheimer’s disease and Parkinson’s disease. Despite the immense biochemical significance of DOPAL, attempts to synthesize this compound in pure form has been met with grave difficulty. Various preparations of DOPAL have been reported, but the synthesis of this eight-carbon compound suffers from detailed procedures, physical isolation, full chemical characterization of the product/intermediates and extremely low overall product yield. These published methods also share one common problem, DOPAL is very unstable and is very difficult to isolate and work with. Therefore, considerable effort to produce DOPAL in a higher yield would be of interest. In an effort to mitigate these problems, we have directed our attention toward the synthesis of DOPAL using organobarium reagents. These novel reagents, fundamental to organic synthesis were utilized in the total synthesis of DOPAL. In addition, we also report the synthesis of the protected DOPAL via a Wittig reaction, but results of the hydrolysis/de-protection protocols have been interesting but unsatisfactory in the isolation of the free aldehyde. These studies may provide important insight on future drug action to combat PD and, when the scope of this research is expanded, may aid in the treatment of other neurodegenerative disorders. |
Mr. Senthilkumar Duraivel | PMSE/POLY | Understading the Aging Process of Porous Polymers |
Mr. SUBHRADEEP DUTTA | Organic Chemistry | Synthesis of Complex Heterocycles via C–H Functionalization of Cyclic Amines |
Mrs. Elly Earlywine | Inorganic Chemistry | Synthesis, structures and magnetic properties of molecular Bi-Mn-oxo and Pb-Mn-oxo clusters |
Mr. Allen Eyler | PMSE/POLY | Biomimetic, Peptide-Directed Synthesis of Magnetic Nanoparticles with Monodisperse Size Distribution |
Ethan Fisher | Inorganic Chemistry | Synthesis of a Ce24 molecular nanoparticle of cerium dioxide with unique surface features |
Mr. John Garrison | PMSE/POLY | Light-Induced Macromolecular Metamorphosis of Polymer Architecture |
Mr. Anthony Giacalone | Biochemistry / Chem Bio. | Real time study of metabolomics for insight into ketogenesis using hyperpolarization in mouse models |
Valentina Gomez | PMSE/POLY | Stimuli-responsive 3 arm star polymers for drug delivery |
Ms. Sofia Goodrich | PMSE/POLY | Polypeptide Synthesis by Photopolymerization of NCAs |
Name | Topic | Title |